Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18305073 | 0.86 | NR3C1 (0.39) | MAPTPDE4BPOLB | |
| SCHEMBL18305086 | 0.85 | NR3C1 (0.37) | MAPTPOLB | |
| SCHEMBL28525837 | 0.84 | MAPT (0.45) | KDM4EMAPTTHRBPDE4BHRH3 | |
| SCHEMBL28907822 | 0.82 | PDE4B (0.52) | KDM4EMAPTTHRBPDE4BDDB1 | |
| SCHEMBL24582307 | 0.76 | GPR119 (0.38) | KDM4EMAPTTHRBGPR119DDB1 | |
| SCHEMBL28298497 | 0.75 | PDE4B (0.56) | KDM4EMAPTTHRBPDE4BGPR119 | |
| SCHEMBL28297779 | 0.75 | PDE4B (0.56) | KDM4EMAPTTHRBPDE4BGPR119 | |
| SCHEMBL30659460 | 0.73 | DDB1 (0.47) | KDM4EMAPTTHRBGPR119DDB1 | |
| SCHEMBL31565100 | 0.73 | DDB1 (0.46) | KDM4EMAPTTHRBGPR119DDB1 | |
| SCHEMBL26985427 | 0.72 | PDE4B (0.58) | KDM4EMAPTTHRBPDE4BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107873031-B | Benzoxazinone derivatives and analogs thereof as modulators of TNF activity | UCB生物制药私人有限公司 | 2021-03-12 | — | — | CN | disclosed |