Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 4/20 | 0.35 |
| ▸ | BRD4 | O60885 | 4/20 | 0.35 |
| ▸ | LIPC | P11150 | 1/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 7/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | RXRA | P19793 | 3/20 | 0.30 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.30 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20138131 | 0.86 | PARP1 (0.34) | CREBBPBRD4PARP1PDE3BPDE3A | |
| SCHEMBL28909618 | 0.81 | NR3C2 (0.43) | CREBBPBRD4LIPCLIPGDRD2 | |
| SCHEMBL28525837 | 0.71 | MAPT (0.45) | — | |
| SCHEMBL18128118 | 0.68 | PARP1 (0.38) | BRD4PARP1PDE3BPDE3ADRD2 | |
| SCHEMBL18127979 | 0.68 | PARP1 (0.38) | BRD4PARP1PDE3BPDE3ADRD2 | |
| SCHEMBL28907820 | 0.67 | KDM4E (0.45) | PARP1PDE3BPDE3A | |
| SCHEMBL20137948 | 0.67 | CYP11B2 (0.41) | PARP1PDE3BPDE3A | |
| SCHEMBL18128043 | 0.67 | PARP1 (0.44) | BRD4PARP1PDE3BPDE3ACECR2 | |
| SCHEMBL30806796 | 0.67 | PARP1 (0.44) | BRD4PARP1PDE3BPDE3ACECR2 | |
| SCHEMBL16792483 | 0.67 | PARP1 (0.44) | BRD4PARP1PDE3BPDE3ACECR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107873031-B | Benzoxazinone derivatives and analogs thereof as modulators of TNF activity | UCB生物制药私人有限公司 | 2021-03-12 | — | — | CN | disclosed |