Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7865136 | 0.95 | SLC6A4 (0.43) | SLC6A4DRD2HTR2AHTR2CNR1H4 | |
| SCHEMBL10571544 | 0.94 | SLC6A4 (0.42) | SLC6A4DRD2HTR2AHTR2CNR1H4 | |
| SCHEMBL7993434 | 0.79 | HTR2A (0.40) | SLC6A4DRD2HTR2AHTR2CCHRM5 | |
| Hydrochloric Acid SCHEMBL8688971 | 0.78 | HTR2A (0.42) | SLC6A4DRD2HTR2AHTR2CCHRM5 | |
| SCHEMBL31172103 | 0.75 | SLC6A4 (0.61) | SLC6A4DRD2CHRM5CHRM3CHRM1 | |
| SCHEMBL28359596 | 0.75 | SLC6A4 (0.61) | SLC6A4DRD2CHRM5CHRM3CHRM1 | |
| SCHEMBL2708963 | 0.75 | SLC6A4 (0.54) | SLC6A4DRD2HTR2AHTR2CNR1H4 | |
| SCHEMBL6685675 | 0.72 | ALOX5 (0.43) | SLC6A4DRD2HTR2AHTR2CALOX5 | |
| SCHEMBL14559239 | 0.72 | SLC6A4 (0.42) | SLC6A4DRD2HTR2AHTR2CCHRM5 | |
| SCHEMBL31412580 | 0.71 | SLC6A4 (0.50) | SLC6A4DRD2HTR2AHTR2CCHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-112010859-B | Fused ring compound, preparation method and application thereof | 中国科学院上海药物研究所 | 2022-07-19 | — | — | CN | disclosed |
| CN-112437772-A | Bcl-2 inhibitors | 百济神州有限公司 | 2021-03-02 | — | — | CN | disclosed |
| CN-112010859-A | Fused ring compound, preparation method and application thereof | 中国科学院上海药物研究所 | 2020-12-01 | — | — | CN | disclosed |