Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10571544 | 0.98 | SLC6A4 (0.42) | SLC6A4DRD2NR1H4HTR2AHTR2C | |
| SCHEMBL28526550 | 0.95 | SLC6A4 (0.43) | SLC6A4DRD2NR1H4HTR2AHTR2C | |
| SCHEMBL7993434 | 0.78 | HTR2A (0.40) | SLC6A4DRD2HTR2AHTR2CCYP2D6 | |
| Hydrochloric Acid SCHEMBL8688971 | 0.77 | HTR2A (0.42) | SLC6A4DRD2HTR2AHTR2CCYP2D6 | |
| SCHEMBL31172103 | 0.74 | SLC6A4 (0.61) | SLC6A4DRD2CYP2A6ALOX5SLC6A2 | |
| SCHEMBL28359596 | 0.74 | SLC6A4 (0.61) | SLC6A4DRD2CYP2A6ALOX5SLC6A2 | |
| SCHEMBL2708963 | 0.73 | SLC6A4 (0.54) | SLC6A4DRD2NR1H4HTR2AHTR2C | |
| SCHEMBL1257399 | 0.72 | POLB (0.53) | CYP2D6CYP2C19POLBCHRNA7CYP1A2 | |
| SCHEMBL1257011 | 0.72 | POLB (0.53) | CYP2D6CYP2C19POLBCHRNA7CYP1A2 | |
| SCHEMBL6685675 | 0.71 | ALOX5 (0.43) | SLC6A4DRD2HTR2AHTR2CCYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077213-A2 | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6046215-A | A PIPERIDINYLBENZOTHIOPHENES USEFUL FOR TRATING BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 2000-04-04 | — | — | US | disclosed |
| US-5846982-A | Inhibition of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0812826-A1 | 1H-indole and benzo(b)thiophene derivatives with 4-(1,2,3,6-tetra:hydro:pyridinyl)- and 4-piperidinyl-groups bound to the heterocyclic ring as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1997-12-17 | — | — | EP | disclosed |