Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2803724 | 0.81 | KDM4E (0.45) | ALDH1A1KDM4EPOLBDRD2TSHR | |
| SCHEMBL9884156 | 0.66 | ADRB1 (0.37) | LMNA | |
| SCHEMBL2800451 | 0.66 | ADRB1 (0.47) | HTR2C | |
| SCHEMBL605479 | 0.65 | ADRB1 (0.46) | HTR2C | |
| SCHEMBL605467 | 0.65 | DRD2 (0.64) | ALDH1A1KDM4EPOLBDRD2TSHR | |
| SCHEMBL2802043 | 0.60 | POLB (0.46) | ALDH1A1KDM4EPOLBDRD2TSHR | |
| Trifluoroacetic Acid SCHEMBL9105391 | 0.60 | ADRB1 (0.40) | — | |
| SCHEMBL605437 | 0.59 | HRH4 (0.48) | — | |
| SCHEMBL604041 | 0.58 | HRH3 (0.34) | — | |
| SCHEMBL2804898 | 0.58 | HTT (0.43) | ALDH1A1KDM4EDRD2TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200595-A2 | THIENO-AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2010-06-30 | — | — | EP | claimed |
| WO-2009038673-A2 | THIENO-AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-26 | — | — | WO | claimed |