Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 4/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL605479 | 0.82 | ADRB1 (0.46) | HTR2CADRB1PRKCI | |
| SCHEMBL2852750 | 0.81 | ALDH1A1 (0.33) | KDM4EALDH1A1POLBHTR2CDRD2 | |
| SCHEMBL605467 | 0.79 | DRD2 (0.64) | KDM4EALDH1A1POLBHTR2CDRD2 | |
| SCHEMBL2802043 | 0.77 | POLB (0.46) | KDM4EALDH1A1POLBHTR2CDRD2 | |
| SCHEMBL2800451 | 0.77 | ADRB1 (0.47) | HTR2CADRB1 | |
| SCHEMBL2800566 | 0.77 | KMT2A (0.48) | KDM4EALDH1A1POLBHTR2CDRD2 | |
| Trifluoroacetic Acid SCHEMBL4126873 | 0.75 | ADRB1 (0.40) | ADRB1PRKCI | |
| SCHEMBL2803722 | 0.74 | HTR2C (0.43) | KDM4EALDH1A1POLBHTR2CDRD2 | |
| SCHEMBL9884156 | 0.71 | ADRB1 (0.37) | ADRB1 | |
| Trifluoroacetic Acid SCHEMBL9105391 | 0.70 | ADRB1 (0.40) | ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200595-A2 | THIENO-AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2010-06-30 | — | — | EP | claimed |
| WO-2009038673-A2 | THIENO-AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-26 | — | — | WO | claimed |