SCHEMBL28527730

SCHEMBL28527730

CCCOC(=O)C(C)(C)N=NC(C)(C)C(=O)O

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.37
LMNA P02545 1/20 0.35
ALDH1A1 P00352 3/20 0.32
GRM1 Q13255 1/20 0.32
CHRM1 P11229 2/20 0.31
CHRM2 P08172 1/20 0.31
CHRM4 P08173 1/20 0.31
CHRM5 P08912 1/20 0.31
CHRM3 P20309 1/20 0.31
ESR1 P03372 1/20 0.31
TSHR P16473 1/20 0.31
SLC6A2 P23975 1/20 0.31
KDR P35968 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
NAAA Q02083 1/20 0.31
DGKA P23743 1/20 0.31
PPM1B O75688 1/20 0.30
PTPN1 P18031 1/20 0.30
PPP1CC P36873 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7594095 0.92 HCAR2 (0.38) HCAR2LMNAALDH1A1GRM1CHRM1
SCHEMBL7594098 0.92 HCAR2 (0.38) HCAR2LMNAALDH1A1GRM1CHRM1
SCHEMBL28530635 0.89 ALDH1A1 (0.44) HCAR2LMNAALDH1A1ESR1TSHR
SCHEMBL11725731 0.84 MGAM (0.39) HCAR2LMNAALDH1A1TSHR
SCHEMBL3937564 0.84 MGAM (0.39) HCAR2LMNAALDH1A1TSHR
SCHEMBL4157874 0.80 ALDH1A1 (0.50) HCAR2LMNAALDH1A1ESR1TSHR
SCHEMBL4157878 0.80 ALDH1A1 (0.50) HCAR2LMNAALDH1A1ESR1TSHR
SCHEMBL491642 0.79 MEN1 (0.37) TSHR
SCHEMBL7575650 0.78 NAAA (0.48) HCAR2LMNAALDH1A1TSHRNAAA
SCHEMBL7575644 0.78 NAAA (0.48) HCAR2LMNAALDH1A1TSHRNAAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108250369-B Preparation method of low-odor high-weather-resistance polymer polyol 万华化学集团股份有限公司 2021-03-09 CN disclosed