SCHEMBL28527952

SCHEMBL28527952

Cc1ccc(S(=O)(=O)NN=C2CC3(CCN(C(=O)OC(C)(C)C)CC3)C2)cc1

nearest known ligand 0.50

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.50
MEN1 O00255 1/20 0.50
MMP13 P45452 2/20 0.48
GPR119 Q8TDV5 10/20 0.47
STS P08842 3/20 0.47
ALDH1A1 P00352 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26631310 0.94 MEN1 (0.46) KMT2AMEN1MMP13GPR119STS
SCHEMBL26738584 0.89 KMT2A (0.47) KMT2AMEN1MMP13GPR119STS
SCHEMBL25408371 0.88 KMT2A (0.46) KMT2AMEN1MMP13GPR119STS
SCHEMBL26738605 0.88 KMT2A (0.46) KMT2AMEN1MMP13GPR119STS
SCHEMBL18137607 0.86 KMT2A (0.54) KMT2AMEN1MMP13GPR119STS
SCHEMBL29139941 0.84 GPR119 (0.42) GPR119STS
SCHEMBL18397145 0.83 KMT2A (0.51) KMT2AMEN1MMP13GPR119STS
SCHEMBL20099653 0.82 KMT2A (0.50) KMT2AMEN1MMP13GPR119STS
SCHEMBL2513062 0.81 KMT2A (0.49) KMT2AMEN1MMP13GPR119STS
SCHEMBL994328 0.81 KMT2A (0.49) KMT2AMEN1MMP13GPR119STS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4652161-A1 2,4-DIANILINOPYRIMIDINE-BASED AURORA-A KINASE SELECTIVE DEGRADATION INDUCING COMPOUNDS Uppthera, Inc. (KR) 2025-11-26 EP disclosed
WO-2024155112-A1 2,4-DIANILINOPYRIMIDINE-BASED AURORA-A KINASE SELECTIVE DEGRADATION INDUCING COMPOUNDS UPPTHERA, INC. (KR) 2024-07-25 WO disclosed
CN-112437772-A Bcl-2 inhibitors 百济神州有限公司 2021-03-02 CN disclosed