Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032586 | 0.90 | TDP1 (0.50) | PRSS1PRSS2PRSS3F10CYP2C19 | |
| SCHEMBL28335414 | 0.83 | F2 (0.47) | CYP2C19F2HDAC2HDAC8HDAC6 | |
| SCHEMBL2850555 | 0.82 | LMNA (0.53) | PRSS1PRSS2PRSS3CYP2C19F2 | |
| SCHEMBL2852808 | 0.81 | CYP19A1 (0.57) | BRAFPRSS1PRSS2PRSS3F2 | |
| SCHEMBL3649154 | 0.80 | PTPN11 (0.57) | PRSS1PRSS2PRSS3CYP2C19F2 | |
| SCHEMBL5041380 | 0.79 | CYP2C19 (0.49) | PRSS1PRSS2PRSS3CYP2C19F2 | |
| SCHEMBL5034887 | 0.78 | CYP2C19 (0.76) | PRSS1PRSS2PRSS3F10CYP2C19 | |
| SCHEMBL2859691 | 0.78 | CYP2C19 (0.55) | PRSS1PRSS2PRSS3F10CYP2C19 | |
| SCHEMBL28208130 | 0.78 | ADAMTS4 (0.50) | PRSS1PRSS2PRSS3F10CYP2C19 | |
| SCHEMBL2854385 | 0.77 | LMNA (0.56) | PRSS1PRSS2PRSS3F2HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |