Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | YAP1 | P46937 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | STS | P08842 | 1/20 | 0.47 |
| ▸ | CPB1 | P15086 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2852833 | 1.00 | HSD11B1 (0.48) | HSD11B1HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30661643 | 1.00 | HSD11B1 (0.48) | HSD11B1HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30400055 | 1.00 | HSD11B1 (0.48) | HSD11B1HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3388401 | 0.92 | PDE4B (0.54) | HSD11B1HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3388396 | 0.92 | PDE4B (0.54) | HSD11B1HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13315211 | 0.92 | PDE4B (0.54) | HSD11B1HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1355893 | 0.92 | PDE4B (0.54) | HSD11B1HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19918950 | 0.92 | PDE4B (0.54) | HSD11B1HTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13737268 | 0.91 | PDE4B (0.50) | HTTNPC1RAB9ASMN1; SMN2STS | |
| SCHEMBL13737266 | 0.91 | PDE4B (0.50) | HTTNPC1RAB9ASMN1; SMN2STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137574-B | Hydroxyalkyl thiadiazole derivatives | 第一三共株式会社 | 2021-12-28 | — | — | CN | disclosed |
| US-10752647-B2 | N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-08-25 | — | — | US | disclosed |
| EP-3356361-B1 | HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2020-07-08 | — | — | EP | disclosed |
| US-20200040019-A1 | N-PHOSPHONOXYMETHL PRODRUGS OF HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2020-02-06 | — | — | US | disclosed |
| US-10399968-B2 | Hydroxyalkyl thiadiazole derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-09-03 | — | — | US | disclosed |
| US-20180327399-A1 | HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-11-15 | — | — | US | disclosed |
| WO-2018169092-A1 | N-PHOSPHONOXYMETHYL PRODRUGS OF HYDROXYALKYL THIADIAZOLE DERIVATIVES | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-09-20 | — | — | WO | disclosed |
| EP-2226322-B1 | IMIDAZOLE CARBONYL COMPOUND | DAIICHI SANKYO CO LTD (JP) | 2015-01-21 | — | — | EP | disclosed |
| US-8927588-B2 | Imidazole carbonyl compound | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-01-06 | — | — | US | disclosed |
| US-20140073622-A1 | IMIDAZOLE CARBONYL COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-03-13 | — | — | US | disclosed |
| US-8536197-B2 | Imidazole carbonyl compound | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-09-17 | — | — | US | disclosed |
| US-20100311966-A1 | IMIDAZOLE CARBONYL COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-12-09 | — | — | US | disclosed |
| EP-2226322-A1 | IMIDAZOLE CARBONYL COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2010-09-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10399968-B2 | Hydroxyalkyl thiadiazole derivatives | TOP1, TOP2B, TOP2A | HSD11B1 37/4885HTT 3364/4885NPC1 3750/4885 |
| US-10752647-B2 | N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives | PHYKPL, SLC34A1, PNKP | HSD11B1 59/4885HTT 4479/4885NPC1 1749/4885 |
| US-20200040019-A1 | N-PHOSPHONOXYMETHL PRODRUGS OF HYDROXYALKYL THIADIAZOLE DERIVATIVES | PHYKPL, SLC34A1, PNKP | HSD11B1 41/4885HTT 4384/4885NPC1 1606/4885 |
| US-20100311966-A1 | IMIDAZOLE CARBONYL COMPOUND | TOP1, TOP2B, TOP2A | HSD11B1 2069/4885HTT 4384/4885NPC1 1573/4885 |
| US-20180327399-A1 | HYDROXYALKYL THIADIAZOLE DERIVATIVES | TOP1, TOP2B, TOP2A | HSD11B1 37/4885HTT 3364/4885NPC1 3750/4885 |
| US-20140073622-A1 | IMIDAZOLE CARBONYL COMPOUND | TOP1, TOP2B, TOP2A | HSD11B1 645/4885HTT 4571/4885NPC1 630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.