Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.67 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.67 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.67 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.67 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.67 |
| ▸ | MAP3K2 | Q9Y2U5 | 2/20 | 0.67 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.49 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2853007 | 0.90 | MAPK11 (0.58) | MAPK14MAPK11DDR1DDR2MAP3K20 | |
| SCHEMBL2856270 | 0.90 | MAPK14 (0.56) | MAPK14MAPK11DDR1DDR2MAP3K20 | |
| SCHEMBL2854446 | 0.89 | MAPK11 (0.55) | MAPK14MAPK11DDR1DDR2MAP3K20 | |
| SCHEMBL2853087 | 0.87 | MAPK11 (0.53) | MAPK14MAPK11DDR1DDR2MAP3K20 | |
| SCHEMBL2856647 | 0.86 | MAPK11 (0.52) | MAPK14MAPK11DDR1DDR2MAP3K20 | |
| SCHEMBL2856642 | 0.83 | HPGD (0.63) | MAPK14MAPK11DDR1DDR2MAP3K20 | |
| SCHEMBL2852100 | 0.82 | MAPK11 (0.49) | MAPK14MAPK11DDR1DDR2MAP3K20 | |
| SCHEMBL2852540 | 0.82 | KDM4E (0.66) | MAPK14MAPK11DDR1DDR2MAP3K20 | |
| SCHEMBL2855979 | 0.81 | CNR1 (0.57) | MAPK14MAPK11DDR1DDR2MAP3K20 | |
| Sr-321 SCHEMBL29583231 | 0.81 | MAPK14 (1.00) | MAPK14MAPK11DDR1DDR2MAP3K20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |