Sr-321

Sr-321

SCHEMBL29583231

O=C(NCCCC1CCCCC1)c1ccc(CNC(=O)c2cnn(-c3ccccc3)c2C(F)(F)F)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 19/20 1.00
MAPK11 Q15759 8/20 1.00
DDR1 Q08345 4/20 1.00
DDR2 Q16832 4/20 1.00
MAP3K20 Q9NYL2 3/20 1.00
MAP3K2 Q9Y2U5 2/20 1.00
TMEM97 Q5BJF2 1/20 1.00
TNF P01375 1/20 0.79
KIT P10721 1/20 0.79
MYLK4 Q86YV6 1/20 0.79
RPS6KA6 Q9UK32 1/20 0.79
ABL1 P00519 1/20 0.55
FGFR3 P22607 1/20 0.55
MAP3K4 Q9Y6R4 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sr-318 SCHEMBL30797858 0.88 MAPK14 (1.00) MAPK14MAPK11DDR1DDR2MAP3K20
SCHEMBL2852950 0.81 MAPK14 (0.67) MAPK14MAPK11DDR1DDR2MAP3K20
SCHEMBL2861147 0.81 KDM4E (0.67) MAPK14MAPK11DDR1DDR2MAP3K20
SCHEMBL2860213 0.80 KDM4E (0.73) MAPK14MAPK11DDR1DDR2MAP3K20
SCHEMBL2852102 0.79 ALDH1A1 (0.67) MAPK14MAPK11DDR1DDR2MAP3K20
SCHEMBL2860464 0.78 KDM4E (0.65) MAPK14MAPK11DDR1DDR2MAP3K20
SCHEMBL2855315 0.78 KDM4E (0.65) MAPK14MAPK11DDR1DDR2MAP3K20
SCHEMBL2850153 0.77 KDM4E (0.63) MAPK14MAPK11DDR1DDR2MAP3K20
SCHEMBL10367088 0.75 ALDH1A1 (0.68) MAPK14MAPK11DDR1DDR2MAP3K20
SCHEMBL2854390 0.75 KDM4E (0.61) MAPK14MAPK11DDR1DDR2MAP3K20

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260115195-A1 CAFFEINE SUSTAINED RELEASE FORMULATION PROLEVI BIO AB (SE) 2026-04-30 US disclosed
US-12441305-B2 Vehicle control device HITACHI ASTEMO, LTD. (JP) 2025-10-14 US disclosed
US-20240254485-A1 SIRNAS TARGETING SLC10A1 TRANSCRIPTS, COMPOSITIONS AND USES THEREOF Hemoshear Therapeutics, Inc. 2024-08-01 US disclosed
US-20230391320-A1 VEHICLE CONTROL DEVICE HITACHI ASTEMO, LTD. (JP) 2023-12-07 US disclosed
EP-4114522-A1 METHODS OF INHIBITING MASP-2 FOR THE TREATMENT AND/OR PREVENTION OF CORONAVIRUS-INDUCED ACUTE RESPIRATORY DISTRESS SYNDROME Omeros Corporation (US) 2023-01-11 EP disclosed
WO-2022097387-A1 VEHICLE CONTROL DEVICE 日立Astemo株式会社 2022-05-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260115195-A1 CAFFEINE SUSTAINED RELEASE FORMULATION SLC5A7, PDE7A, SLC6A2 MAPK14 2077/4885MAPK11 592/4885DDR1 2239/4885
US-20240254485-A1 SIRNAS TARGETING SLC10A1 TRANSCRIPTS, COMPOSITIONS AND USES THEREOF SLC20A1, SLC10A1, SLC10A6 MAPK14 4792/4885MAPK11 4593/4885DDR1 2601/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.