Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16376282 | 0.88 | SMN1; SMN2 (0.37) | SMN1; SMN2ALDH1A1MAPK1POLBMEN1 | |
| SCHEMBL22445908 | 0.84 | APOBEC3A (0.41) | SMN1; SMN2ALDH1A1APOBEC3AAPOBEC3GKDM4E | |
| SCHEMBL28524393 | 0.83 | APOBEC3A (0.41) | SMN1; SMN2ALDH1A1APOBEC3AAPOBEC3GKDM4E | |
| SCHEMBL15175180 | 0.81 | NOTUM (0.43) | SMN1; SMN2ALDH1A1KDM4EPOLBRXFP1 | |
| SCHEMBL28527557 | 0.79 | KCNH2 (0.41) | ALDH1A1APOBEC3AAPOBEC3GKDM4EPOLB | |
| SCHEMBL24662921 | 0.78 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1MAPK1KDM4EPOLB | |
| SCHEMBL26664258 | 0.74 | RXFP1 (0.45) | SMN1; SMN2ALDH1A1MAPK1APOBEC3AAPOBEC3G | |
| SCHEMBL30727779 | 0.73 | SMN1; SMN2 (0.33) | SMN1; SMN2ALDH1A1MAPK1KMT2A | |
| SCHEMBL25359012 | 0.73 | PDE4B (0.32) | SMN1; SMN2ALDH1A1MAPK1KDM4EPOLB | |
| SCHEMBL16376293 | 0.73 | ALDH1A1 (0.35) | SMN1; SMN2ALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112469707-B | Preventive or therapeutic agent for spinal muscular atrophy | 利伯纳生物科学株式会社 | 2024-06-21 | — | — | CN | disclosed |
| CN-108473510-B | Process for preparing 2-pyrazolo [1,5-a ] pyrazin-2-ylpyrido [1,2-a ] pyrimidin-4-one | 豪夫迈·罗氏有限公司 | 2021-10-29 | — | — | CN | disclosed |
| CN-112469707-A | Prophylactic or therapeutic agent for spinal muscular atrophy | 利伯纳生物科学株式会社 | 2021-03-09 | — | — | CN | disclosed |