Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 5/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 5/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16832665 | 0.84 | KDM4E (0.57) | KDM4EALDH1A1GAATSHRHSD17B10 | |
| SCHEMBL28536559 | 0.80 | L3MBTL1 (0.60) | KDM4EALDH1A1MAPK1SMN1; SMN2MEN1 | |
| SCHEMBL28540684 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL28046850 | 0.79 | ALOX15 (0.55) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL28535854 | 0.79 | KDM4E (0.64) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL8366862 | 0.78 | KDM4E (0.53) | KDM4EALDH1A1GAATSHRHSD17B10 | |
| SCHEMBL28540687 | 0.78 | KDM4E (0.58) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL28535269 | 0.75 | KDM4E (0.46) | KDM4EALDH1A1GAATSHRHPGD | |
| SCHEMBL21940198 | 0.74 | POLB (0.72) | KDM4EALDH1A1GAAHSD17B10MAPK1 | |
| SCHEMBL28046848 | 0.74 | KDM4E (0.55) | KDM4EALDH1A1HPGDGLAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109467549-B | Quinoline-substituted chalcone compound, preparation method and application thereof | 中国药科大学 | 2021-02-09 | — | — | CN | disclosed |