Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 3/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.46 |
| ▸ | WEE1 | P30291 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28953583 | 0.91 | EGFR (0.49) | PLK1ALKEGFRPKMYT1WEE1 | |
| SCHEMBL28953570 | 0.88 | PKMYT1 (0.49) | PLK1ALKEGFRPKMYT1WEE1 | |
| SCHEMBL21600797 | 0.87 | EGFR (0.51) | PLK1EGFRMAPK3 | |
| SCHEMBL28531632 | 0.84 | FGFR1 (0.47) | PLK1ALKEGFRWEE1LRRK2 | |
| SCHEMBL28910563 | 0.78 | SLC2A1 (0.48) | ALKPKMYT1WEE1LRRK2FGFR1 | |
| SCHEMBL21600822 | 0.77 | EGFR (0.49) | PLK1EGFRMAPK3 | |
| SCHEMBL28525553 | 0.77 | EGFR (0.53) | PLK1EGFRMAPK3 | |
| SCHEMBL21596382 | 0.75 | EGFR (0.51) | EGFRMAPK3 | |
| SCHEMBL28546937 | 0.73 | JAK3 (0.47) | PKMYT1LRRK2 | |
| SCHEMBL21600795 | 0.72 | JAK3 (0.51) | PLK1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |