Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 8/20 | 0.46 |
| ▸ | EGFR | P00533 | 5/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | SELP | P16109 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28953583 | 0.89 | EGFR (0.49) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL28531630 | 0.85 | MAPK3 (0.51) | PLK1EGFRMAPK1JAK3 | |
| SCHEMBL28953581 | 0.85 | SYK (0.49) | FGFR1SYKALKAURKAMAP4K4 | |
| SCHEMBL28531544 | 0.84 | PLK1 (0.51) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL28546192 | 0.83 | PLK1 (0.57) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL21600938 | 0.82 | EGFR (0.50) | PLK1EGFRMAPK1JAK3 | |
| SCHEMBL21600984 | 0.78 | EGFR (0.47) | EGFRINSRMAPK1 | |
| SCHEMBL21600796 | 0.77 | EGFR (0.52) | PLK1EGFRINSRMAPK1JAK3 | |
| SCHEMBL21600815 | 0.76 | MAPK3 (0.44) | SYKEGFRMAPK1JAK3 | |
| SCHEMBL28910563 | 0.75 | SLC2A1 (0.48) | FGFR1SYKALKAURKAMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |