SCHEMBL28532243

SCHEMBL28532243

c1ccc([SiH](CCc2ccc3ccccc3c2)c2ccccc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.52
CYP2A6 P11509 1/20 0.52
SIGMAR1 Q99720 3/20 0.46
HRH3 Q9Y5N1 1/20 0.45
KMT2A Q03164 1/20 0.42
SLC13A5 Q86YT5 1/20 0.42
PDPK1 O15530 1/20 0.42
SLC6A4 P31645 1/20 0.41
SOX18 P35713 1/20 0.41
HTR2A P28223 1/20 0.41
HTR2C P28335 1/20 0.41
HTR2B P41595 1/20 0.41
HDAC1 Q13547 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
BACE1 P56817 1/20 0.39
PLAU P00749 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25909608 0.78 ALDH1A1 (0.46) CYP1A2CYP2A6SIGMAR1HTR2A
SCHEMBL29560700 0.77 CYP1A2 (0.65) CYP1A2CYP2A6SIGMAR1HRH3KMT2A
SCHEMBL6240981 0.77 CYP1A2 (0.65) CYP1A2CYP2A6SIGMAR1HRH3KMT2A
SCHEMBL3153426 0.77 CYP1A2 (0.50) CYP1A2CYP2A6SIGMAR1HRH3KMT2A
SCHEMBL8670812 0.76 PLAU (0.59) CYP1A2CYP2A6SIGMAR1HRH3KMT2A
SCHEMBL25909610 0.75 FFAR1 (0.47)
SCHEMBL30418669 0.73 SIGMAR1 (0.68) CYP1A2CYP2A6SIGMAR1HRH3SLC6A4
SCHEMBL30746339 0.73 SIGMAR1 (0.68) CYP1A2CYP2A6SIGMAR1HRH3SLC6A4
SCHEMBL28533680 0.73 TAAR1 (0.43) SIGMAR1PDPK1HTR2A
SCHEMBL25909607 0.73 CYP1A2 (0.43) CYP1A2CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112387313-B Tridentate phenanthroline manganese catalyst and application thereof in synthesis of organic silicon/boron compound 中山大学 2022-08-16 CN disclosed
CN-112387313-A Tridentate phenanthroline manganese catalyst and application thereof in synthesis of organic silicon/boron compound 中山大学 2021-02-23 CN disclosed