Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.73 |
| ▸ | MAPT | P10636 | 4/20 | 0.73 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.66 |
| ▸ | GAA | P10253 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856945 | 0.87 | ALDH1A1 (0.81) | ALDH1A1MAPTMAPK14GAAMAPK1 | |
| SCHEMBL14097123 | 0.84 | MAPT (0.78) | ALDH1A1MAPTMAPK14GAAMAPK1 | |
| SCHEMBL2326321 | 0.83 | ALDH1A1 (0.68) | ALDH1A1MAPTMAPK14GAAMAPK1 | |
| SCHEMBL2855555 | 0.83 | TRPC1 (0.61) | ALDH1A1MAPTGAASMN1; SMN2RAB9A | |
| SCHEMBL4961243 | 0.79 | ALDH1A1 (0.57) | ALDH1A1MAPTMAPK14GAAMAPK1 | |
| SCHEMBL2856762 | 0.78 | ALDH1A1 (0.77) | ALDH1A1MAPTMAPK14GAAMAPK1 | |
| SCHEMBL14097124 | 0.78 | ALDH1A1 (0.67) | ALDH1A1MAPTMAPK14GAAMAPK1 | |
| SCHEMBL4959888 | 0.78 | ALDH1A1 (0.56) | ALDH1A1MAPTMAPK14GAAMAPK1 | |
| SCHEMBL1402961 | 0.78 | HSD11B1 (0.57) | ALDH1A1MAPTMAPK14GAAMAPK1 | |
| SCHEMBL18733483 | 0.77 | ALDH1A1 (0.65) | ALDH1A1MAPTMAPK14GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |