Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 2/20 | 0.75 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.66 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.62 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.57 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.57 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.57 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.57 |
| ▸ | RHOC | P08134 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4286068 | 0.87 | MAPT (0.94) | KCNK3MAPTLMNAKCNK9MEN1 | |
| SCHEMBL2853215 | 0.83 | KCNK3 (0.79) | KCNK3MAPTLMNAKCNK9MEN1 | |
| SCHEMBL22065212 | 0.83 | PTGS1 (0.80) | KCNK3MAPTLMNAKCNK9MEN1 | |
| SCHEMBL4517587 | 0.83 | LMNA (1.00) | KCNK3MAPTLMNAKCNK9MEN1 | |
| SCHEMBL30739929 | 0.83 | LMNA (1.00) | KCNK3MAPTLMNAKCNK9MEN1 | |
| SCHEMBL2860185 | 0.82 | BRAF (0.60) | KCNK3KCNK9 | |
| SCHEMBL2859341 | 0.82 | MEN1 (0.78) | KCNK3MAPTLMNAKCNK9MEN1 | |
| SCHEMBL15094033 | 0.82 | MAPT (0.78) | KCNK3MAPTLMNAKCNK9MEN1 | |
| SCHEMBL4656855 | 0.82 | MAPT (0.78) | KCNK3MAPTLMNAKCNK9MEN1 | |
| SCHEMBL2494871 | 0.82 | KCNK3 (0.81) | KCNK3MAPTLMNAKCNK9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184285-B1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2015-11-04 | — | — | EP | disclosed |
| US-8344135-B2 | Heterocyclic compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-01-01 | — | — | US | disclosed |
| US-20100249119-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | US | disclosed |
| EP-2184285-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-05-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249119-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | BRAF, NRAS, RAF1 | KCNK3 4111/4885MAPT 4439/4885LMNA 4482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.