SCHEMBL28533596

SCHEMBL28533596

Cc1cc(Br)cc(C(=O)NC(C)CC#N)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl

nearest known ligand 0.63

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.39
MALT1 Q9UDY8 1/20 0.33
LMNA P02545 1/20 0.32
KCNH2 Q12809 4/20 0.32
GCK P35557 3/20 0.32
CAPN1 P07384 1/20 0.32
S1PR3 Q99500 2/20 0.31
S1PR1 P21453 1/20 0.31
AR P10275 2/20 0.31
NTRK1 P04629 3/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28533590 0.94 DHODH (0.39) DHODHMALT1KCNH2GCKCAPN1
SCHEMBL28531383 0.94 DHODH (0.37) DHODHLMNAKCNH2GCKCAPN1
SCHEMBL28532146 0.93 DHODH (0.39) DHODHMALT1KCNH2GCKCAPN1
SCHEMBL28908828 0.89 DHODH (0.37) DHODHKCNH2GCKCAPN1NTRK1
SCHEMBL782222 0.89 DHODH (0.43) DHODHMALT1LMNAKCNH2CAPN1
SCHEMBL28525390 0.88 DHODH (0.37) DHODHKCNH2GCKCAPN1S1PR3
SCHEMBL16639217 0.87 DHODH (0.42) DHODHMALT1LMNAKCNH2GCK
SCHEMBL782370 0.84 DHODH (0.44) DHODHMALT1LMNANTRK1
SCHEMBL30058805 0.84 DHODH (0.44) DHODHMALT1LMNANTRK1
SCHEMBL563173 0.84 DHODH (0.41) DHODHMALT1KCNH2GCKCAPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110066270-B Polyamide compound and preparation method and application thereof 湖南化工研究院有限公司 2021-02-26 CN claimed
CN-110066270-B Polyamide compound and preparation method and application thereof 湖南化工研究院有限公司 2021-02-26 CN disclosed