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Sugi Predict / Compounds / SCHEMBL563173

SCHEMBL563173

SCHEMBL563173

Cc1cc(C#N)cc(C(=O)NC(C)C)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl

nearest known ligand 0.67

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ DHODH Q02127 3/20 0.41
▸ KCNH2 Q12809 6/20 0.36
▸ GCK P35557 4/20 0.36
▸ PDE4A P27815 4/20 0.35
▸ EGLN1 Q9GZT9 1/20 0.35
▸ KMT2A Q03164 1/20 0.34
▸ PDE4B Q07343 2/20 0.34
▸ PDE4C Q08493 2/20 0.34
▸ PDE4D Q08499 2/20 0.34
▸ PKM P14618 1/20 0.34
▸ MALT1 Q9UDY8 1/20 0.33
▸ SLC2A1 P11166 1/20 0.32
▸ SLC2A2 P11168 1/20 0.32
▸ SLC2A3 P11169 1/20 0.32
▸ SLC2A4 P14672 1/20 0.32
▸ CAPN1 P07384 1/20 0.32
▸ S1PR3 Q99500 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30078383 1.00 DHODH (0.41) DHODHKCNH2GCKPDE4AEGLN1
SCHEMBL5620274 0.93 DHODH (0.39) DHODHKCNH2GCKPDE4AKMT2A
SCHEMBL10140235 0.93 PDE4A (0.36) DHODHKCNH2PDE4AEGLN1KMT2A
SCHEMBL30078303 0.92 KCNH2 (0.37) DHODHKCNH2GCKPDE4AEGLN1
SCHEMBL563295 0.92 KCNH2 (0.37) DHODHKCNH2GCKPDE4AEGLN1
SCHEMBL28532146 0.91 DHODH (0.39) DHODHKCNH2GCKPDE4AEGLN1
SCHEMBL11893257 0.91 PDE4A (0.36) DHODHKCNH2PDE4AEGLN1KMT2A
SCHEMBL14227757 0.91 DHODH (0.39) DHODHKCNH2GCKPDE4AEGLN1
SCHEMBL15424655 0.91 DHODH (0.39) DHODHKCNH2GCKPDE4AKMT2A
Cyantraniliprole SCHEMBL166640 0.91 DHODH (0.42) DHODHKCNH2GCKPDE4AEGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 127 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7247647-B2 Cyano anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-07-24 — — US claimed
US-20240349727-A1 SYNERGY BETWEEN MIXTURES OF ISOTHIOCYANATES AND COMMERCIAL FUNGICIDES AGROSUSTAIN SA (CH) 2024-10-24 — — US disclosed
CN-117858621-A Synergistic effect between isothiocyanate and mixture of commercial fungicides 农维股份公司 2024-04-09 — — CN disclosed
WO-2020023449-A1 METHODS AND COMPOSITIONS FOR DOWNY MILDEW REDUCTION PIONEER HI-BRED INTERNATIONAL, INC. (US) 2020-01-30 — — WO disclosed
US-10405548-B2 Fungicidal compositions SYNGENTA CROP PROTECTION LLC (US) 2019-09-10 — — US disclosed
EP-2547665-B1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-07-04 — — EP disclosed
US-9949482-B2 Fungicidal compositions SYNGENTA CROP PROTECTION, LLC (US) 2018-04-24 — — US disclosed
US-9771365-B2 Spiroheterocyclic N-oxypiperidines as pesticides SYNGENTA PARTICIPATIONS AG (CH) 2017-09-26 — — US disclosed
US-9771365-B2 Spiroheterocyclic N-oxypiperidines as pesticides SYNGENTA PARTICIPATIONS AG (CH) 2017-09-26 — — US disclosed
EP-2187748-B1 FUNGICIDAL COMPOUNDS AND MIXTURES DU PONT (US) 2017-07-05 — — EP disclosed
US-20090221587-A1 NOVEL INSECTICIDES SYNGENTA CROP PROTECTION, INC. (US) 2009-09-03 — — US disclosed
US-20090149506-A1 INSECTICIDAL COMPOSITIONS WITH IMPROVED EFFECT BAYER CROPSCIENCE AG (DE) 2009-06-11 — — US disclosed
EP-1819695-B1 ANTHRANILAMIDE DERIVATIVES AS INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2008-12-17 — — EP disclosed
US-20080182750-A1 Cyano Anthranilamide Insecticides SYNGENTA CROP PROTECTION, INC. (US) 2008-07-31 — — US disclosed
US-20080146552-A1 Anthranilamide Derivatives as Insecticides SYNGENTA CROP PROTECTION, INC. 2008-06-19 — — US disclosed
US-20080146552-A1 Anthranilamide Derivatives as Insecticides SYNGENTA CROP PROTECTION, INC. 2008-06-19 — — US disclosed
US-20070244073-A1 Pesticidal Mixtures SYNGENTA CROP PROTECTION, INC. (US) 2007-10-18 — — US disclosed
US-20070244073-A1 Pesticidal Mixtures SYNGENTA CROP PROTECTION, INC. (US) 2007-10-18 — — US disclosed
WO-2007020050-A2 BICYCLIC BISAMIDE DERIVATIVES AND USE THEREOF AS INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2007-02-22 — — WO disclosed
WO-2007009661-A2 PESTICIDAL MIXTURES CONTAINING BICYCLIC ANTHRANILAMIDES SYNGENTA PARTICIPATIONS AG (CH) 2007-01-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090149506-A1 INSECTICIDAL COMPOSITIONS WITH IMPROVED EFFECT PTEN, PPA1, NAAA DHODH 1604/4885KCNH2 1003/4885GCK 2186/4885
US-20080146552-A1 Anthranilamide Derivatives as Insecticides DDT, ALDH7A1, AADAC DHODH 235/4885KCNH2 3048/4885GCK 3795/4885
US-20090221587-A1 NOVEL INSECTICIDES DDT, CYP4F11, ACHE DHODH 182/4885KCNH2 1977/4885GCK 3959/4885
US-20070244073-A1 Pesticidal Mixtures ACHE, ATL3, BPHL DHODH 2761/4885KCNH2 1449/4885GCK 3767/4885
US-20080182750-A1 Cyano Anthranilamide Insecticides CRY1, CRYAA, ALDH7A1 DHODH 274/4885KCNH2 2382/4885GCK 3717/4885
US-10405548-B2 Fungicidal compositions PIK3C3, CYP51A1, CYP1B1 DHODH 874/4885KCNH2 499/4885GCK 2902/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.