SCHEMBL28533733

SCHEMBL28533733

Cc1ccc(-c2cc(C#N)ccn2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.47
CYP2A6 P11509 1/20 0.47
GRM5 P41594 4/20 0.44
MAPKAPK2 P49137 1/20 0.44
KDM4E B2RXH2 2/20 0.41
NPSR1 Q6W5P4 2/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
RXFP1 Q9HBX9 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
DYRK1A Q13627 1/20 0.41
CLK4 Q9HAZ1 1/20 0.41
CCR1 P32246 1/20 0.41
CCR5 P51681 1/20 0.41
CCR8 P51685 1/20 0.41
TGFBR1 P36897 2/20 0.40
LRRK2 Q5S007 1/20 0.40
HPGD P15428 1/20 0.40
PPARG P37231 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17116616 0.85 PPARG (0.43) GRM5MAPKAPK2CLK4TGFBR1PPARG
SCHEMBL2326256 0.82 KDM1A (0.43) ALDH1A1CYP2A6KDM4EL3MBTL1CCR1
SCHEMBL15104626 0.82 NPY5R (0.53) ALDH1A1GRM5MAPKAPK2KDM4ESMN1; SMN2
SCHEMBL21101647 0.82 CCR1 (0.55) ALDH1A1CYP2A6GRM5MAPKAPK2CCR1
SCHEMBL28908876 0.82 MEN1 (0.40) GRM5MAPKAPK2CLK4TGFBR1PPARG
SCHEMBL17116566 0.82 CLK4 (0.43) ALDH1A1GRM5MAPKAPK2CLK4TGFBR1
SCHEMBL10202133 0.82 MMP3 (0.52) GRM5MAPKAPK2NPC1RAB9AL3MBTL1
SCHEMBL2949191 0.81 ASIC3 (0.53) ALDH1A1GRM5CLK4TGFBR1PIM1
SCHEMBL30158989 0.81 ASIC3 (0.53) ALDH1A1GRM5CLK4TGFBR1PIM1
SCHEMBL28524044 0.81 MEN1 (0.54) ALDH1A1MAPKAPK2KDM4ENPSR1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112409250-B Direct aromatization process of cyanopyridine 常州工程职业技术学院 2023-02-28 CN disclosed
CN-112409250-A Direct aromatization process of cyanopyridine 常州工程职业技术学院 2021-02-26 CN disclosed