Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.50 |
| ▸ | GRM5 | P41594 | 5/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.49 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.49 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.43 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30158989 | 1.00 | ASIC3 (0.53) | ASIC3CLK4GRM5GABRA1GABRG2 | |
| SCHEMBL17116486 | 0.89 | TDO2 (0.44) | ASIC3CLK4GRM5GABRA1GABRG2 | |
| SCHEMBL9792939 | 0.87 | CLK4 (0.62) | ASIC3CLK4GRM5GABRA1GABRG2 | |
| SCHEMBL18462117 | 0.86 | GRM5 (0.44) | ASIC3CLK4GRM5GABRA1GABRG2 | |
| SCHEMBL16016610 | 0.86 | GABRG2 (0.63) | ASIC3CLK4GRM5GABRA1GABRG2 | |
| SCHEMBL17116600 | 0.85 | CLK4 (0.51) | ASIC3CLK4GRM5GABRA1GABRG2 | |
| SCHEMBL17116616 | 0.85 | PPARG (0.43) | CLK4GRM5GABRA1GABRG2GABRB3 | |
| SCHEMBL17116603 | 0.84 | GRM5 (0.43) | ASIC3CLK4GRM5GABRA1GABRG2 | |
| SCHEMBL17116488 | 0.84 | TGFBR1 (0.46) | ASIC3CLK4GRM5GABRA1GABRG2 | |
| SCHEMBL17116030 | 0.84 | ESR1 (0.43) | ASIC3GRM5GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118955559-A | Method for preparing triarylphosphine and oxide thereof by photoinduction of cyanopyridine | 南京师范大学 | 2024-11-15 | — | — | CN | disclosed |
| CN-115403519-B | Synthesis method of N-substituted isonicotinamide compound driven by visible light | 河南师范大学 | 2024-03-01 | — | — | CN | disclosed |
| WO-2023085123-A1 | ORGANIC COMPOUND AND ORGANIC LIGHT-EMITTING ELEMENT | キヤノン株式会社 | 2023-05-19 | — | — | WO | disclosed |
| CN-112409250-B | Direct aromatization process of cyanopyridine | 常州工程职业技术学院 | 2023-02-28 | — | — | CN | disclosed |
| CN-115403519-A | Synthesis method of N-substituted isonicotinamide compound driven by visible light | 河南师范大学 | 2022-11-29 | — | — | CN | disclosed |
| CN-113582915-A | Synthesis method of 4-substituted pyridine compound | 河南师范大学 | 2021-11-02 | — | — | CN | disclosed |
| CN-107922400-B | Muscarinic M1 receptor positive allosteric modulators | 苏文生命科学有限公司 | 2021-05-11 | — | — | CN | disclosed |
| CN-112409250-A | Direct aromatization process of cyanopyridine | 常州工程职业技术学院 | 2021-02-26 | — | — | CN | disclosed |
| US-10308620-B2 | Muscarinic M1 receptor positive allosteric modulators | SUVEN LIFE SCIENCES LIMITED (IN) | 2019-06-04 | — | — | US | disclosed |
| US-20180155302-A1 | MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | SUVEN LIFE SCIENCES LIMITED (IN) | 2018-06-07 | — | — | US | disclosed |
| WO-2016198937-A1 | MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | SUVEN LIFE SCIENCES LIMITED (IN) | 2016-12-15 | — | — | WO | disclosed |
| CN-103755631-B | The direct aromatize technique of pyridine derivate | CHANGZHOU ENGINEERING VOCATIONAL TECHNICAL COLLEGE (CN) | 2016-03-02 | — | — | CN | disclosed |
| CN-103755631-A | Direct aromatization process of pyridine derivative | CHANGZHOU INST ENG TECH | 2014-04-30 | — | — | CN | disclosed |
| US-7767665-B2 | 3-[6-(4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propionic acid, having an excellent apoptosis inhibitory and Macrophage migration inhibitory factor (MIF) binding effects, used for preventing and/or treating cancers, AIDS, cardiovascular, neurodegeneartive, bone, kidney and liver disoders | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-03 | — | — | US | disclosed |
| US-20090082343-A1 | 1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-03-26 | — | — | US | disclosed |
| US-7399759-B2 | 1, 3-benzothiazinone derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-15 | — | — | US | disclosed |
| US-20050032786-A1 | 1, 3-benzothiazinone derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-02-10 | — | — | US | disclosed |
| EP-1424336-A1 | 1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2004-06-02 | — | — | EP | disclosed |
| US-6603007-B1 | Intermediates in the fields of pharmaceuticals, agrichemicals, ligands, silver halide photosensitive materials, liquid crystals, surfactants, electrophotography and organic electroluminescence | SANKIO CHEMICAL CO., LTD. (JP) | 2003-08-05 | — | — | US | disclosed |
| EP-1231207-A1 | NOVEL BIPYRIDYL DERIVATIVES | Sankio Chemical Co., Ltd. (JP) | 2002-08-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090082343-A1 | 1,3-BENZOTHIAZINONE DERIVATIVES AND USE THEREOF | MIF, MORF4L1, FOXM1 | ASIC3 2941/4885CLK4 2739/4885GRM5 2620/4885 |
| US-10308620-B2 | Muscarinic M1 receptor positive allosteric modulators | CHRM1, CHRM2, CHRM3 | ASIC3 801/4885CLK4 3540/4885GRM5 43/4885 |
| US-20180155302-A1 | MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | CHRM1, CHRM2, CHRM3 | ASIC3 801/4885CLK4 3540/4885GRM5 43/4885 |
| US-20050032786-A1 | 1, 3-benzothiazinone derivatives and use thereof | MIF, MORF4L1, FOXM1 | ASIC3 2941/4885CLK4 2739/4885GRM5 2620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.