Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 8/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24775589 | 1.00 | OPRM1 (0.38) | OPRM1OPRK1HTR2CHTR1ASLC6A2 | |
| SCHEMBL26779745 | 0.88 | HTR2C (0.46) | OPRM1OPRK1HTR2CHTR1ASLC6A2 | |
| SCHEMBL24775597 | 0.80 | OPRM1 (0.43) | OPRM1OPRK1HTR2CHTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL28535225 | 0.79 | OPRM1 (0.42) | OPRM1OPRK1HTR2CHTR2AHTR2B | |
| SCHEMBL23578824 | 0.78 | OPRM1 (0.37) | OPRM1OPRK1HTR2CHTR1ASLC6A2 | |
| SCHEMBL23579330 | 0.78 | OPRM1 (0.37) | OPRM1OPRK1HTR2CHTR1ASLC6A2 | |
| SCHEMBL29747612 | 0.78 | OPRM1 (0.37) | OPRM1OPRK1HTR2CHTR1ASLC6A2 | |
| SCHEMBL30150849 | 0.78 | OPRM1 (0.37) | OPRM1OPRK1HTR2CHTR1ASLC6A2 | |
| SCHEMBL31198398 | 0.75 | GPR119 (0.53) | — | |
| SCHEMBL28519485 | 0.75 | GPR119 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-112437772-A | Bcl-2 inhibitors | 百济神州有限公司 | 2021-03-02 | — | — | CN | disclosed |