Isoleucine

Isoleucine

SCHEMBL28534804

CC(O)CC(=O)NC(C)C(=O)O.CCC(C)C(N)C(=O)O

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MME P08473 1/20 0.45
ACE P12821 1/20 0.45
CPA1 P15085 1/20 0.45
ACE2 Q9BYF1 1/20 0.45
FAAH O00519 4/20 0.39
ALDH1A1 P00352 4/20 0.37
MAPT P10636 1/20 0.37
SMN1; SMN2 Q16637 3/20 0.35
KDM4E B2RXH2 2/20 0.35
TSHR P16473 1/20 0.35
SLC6A5 Q9Y345 1/20 0.35
SLC7A5 Q01650 1/20 0.34
DPP4 P27487 1/20 0.34
DPP8 Q6V1X1 1/20 0.34
DPP9 Q86TI2 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.32
ENPEP Q07075 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Valine SCHEMBL28546102 0.85 SLC7A5 (0.52) MMEACECPA1ACE2FAAH
SCHEMBL1644161 0.83 FAAH (0.46) MMEACECPA1ACE2FAAH
SCHEMBL1644160 0.83 FAAH (0.46) MMEACECPA1ACE2FAAH
Isoleucine SCHEMBL28220228 0.80 MME (0.44) MMEACECPA1ACE2FAAH
Isoleucine SCHEMBL27720818 0.79 SLC7A5 (0.52) ALDH1A1SLC7A5DPP4DPP8DPP9
Isoleucine SCHEMBL27720816 0.79 SLC7A5 (0.52) ALDH1A1SLC7A5DPP4DPP8DPP9
Glycine SCHEMBL28537104 0.78 FAAH (0.41) MMEACECPA1ACE2FAAH
SCHEMBL21261484 0.78 MME (0.53) MMEACECPA1ACE2ALDH1A1
Isoleucine SCHEMBL1255583 0.77 SLC7A5 (0.55) ALDH1A1SLC7A5DPP4DPP8DPP9
Isoleucine SCHEMBL8045737 0.77 SLC7A5 (0.55) ALDH1A1SLC7A5DPP4DPP8DPP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108017555-B Beta-hydroxybutyryl-amino acid compound and preparation method and application thereof 郑州海斯威生物技术有限公司 2021-03-26 CN disclosed