Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | MLYCD | O95822 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854871 | 0.86 | KCNA5 (0.39) | FFAR4HSD11B1MGLLEPHX1 | |
| SCHEMBL2854859 | 0.82 | NOTUM (0.47) | NOTUM | |
| SCHEMBL18825893 | 0.74 | NOTUM (0.71) | NOTUMFFAR4HSD11B1CHRM4MGLL | |
| SCHEMBL27832133 | 0.68 | NOTUM (0.42) | NOTUMFFAR4EPHX1DHFRACACB | |
| SCHEMBL3711341 | 0.68 | DHFR (0.49) | NOTUMFFAR4CHRM4DHFRPDE4B | |
| SCHEMBL6498392 | 0.68 | NOTUM (0.85) | NOTUMFFAR4CHRM4PDE4BPDE4D | |
| SCHEMBL27999922 | 0.67 | NOTUM (0.61) | NOTUMFFAR4CHRM4DHFRFAAH | |
| SCHEMBL3707661 | 0.66 | SCD (0.52) | NOTUMFFAR4CHRM4DHFRFAAH | |
| SCHEMBL9273396 | 0.66 | NOTUM (0.59) | NOTUMFFAR4HSD11B1CHRM4MGLL | |
| SCHEMBL5239776 | 0.66 | KMT2A (0.71) | NOTUMEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |