Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfadoxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.97 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CCR4 | P51679 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfadoxine SCHEMBL29390814 | 0.99 | ESR1 (1.00) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL41069 | 0.99 | ESR1 (1.00) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL28436237 | 0.97 | ESR1 (0.97) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL27856131 | 0.97 | ESR1 (0.97) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL28359083 | 0.97 | ESR1 (0.97) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL615997 | 0.94 | ESR1 (0.90) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL28122268 | 0.93 | ESR1 (0.88) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL30005494 | 0.91 | ESR1 (0.86) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL28198178 | 0.90 | ESR1 (0.82) | ESR1MEN1KMT2ACYP2C19LMNA | |
| SCHEMBL31548600 | 0.85 | ESR1 (0.76) | ESR1MEN1KMT2ALMNACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112592319-A | Refining method of high-quality sulfadoxine | 重庆康乐制药有限公司 | 2021-04-02 | — | — | CN | disclosed |
| CN-112592319-A | Refining method of high-quality sulfadoxine | 重庆康乐制药有限公司 | 2021-04-02 | — | — | CN | disclosed |