Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfadoxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CCR4 | P51679 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfadoxine SCHEMBL29390814 | 1.00 | ESR1 (1.00) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL28359083 | 0.99 | ESR1 (0.97) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL27856131 | 0.99 | ESR1 (0.97) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL28436237 | 0.99 | ESR1 (0.97) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL28537335 | 0.99 | ESR1 (0.97) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL615997 | 0.95 | ESR1 (0.90) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL28122268 | 0.94 | ESR1 (0.88) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL30005494 | 0.92 | ESR1 (0.86) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL28198178 | 0.91 | ESR1 (0.82) | ESR1MEN1KMT2ACYP2C19LMNA | |
| SCHEMBL31548600 | 0.86 | ESR1 (0.76) | ESR1MEN1KMT2ALMNACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 13490 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| EP-3790536-B1 | NANOCONTAINERS FOR TRANSPORTING NONPOLAR, LIPOPHILIC SUBSTANCES SUCH AS ANTIBIOTICS | KARLSRUHER INST TECHNOLOGIE (DE) | 2026-04-22 | — | — | EP | claimed |
| EP-4724049-A1 | MODIFIED RELEASE FILL COMPOSITIONS FOR DOSAGE FORMS AND METHODS OF PREPARATION AND USE THEREOF | Catalent Ontario Limited (CA) | 2026-04-15 | — | — | EP | claimed |
| CN-121577779-A | Method for detecting carcinogen in sulfadoxine | 桂林南药股份有限公司 | 2026-02-27 | — | — | CN | claimed |
| US-20260027140-A1 | COMPOSITIONS AND METHODS FOR TREATING AND AMELIORATING RESPIRATORY CONDITIONS AND INFLAMMATION OF MUCOSA | ATOPIC MEDICAL INC (US) | 2026-01-29 | — | — | US | claimed |
| EP-4680248-A1 | PRODUCTS OF MANUFACTURE AND THERAPEUTIC COMPOSITIONS FOR TREATING, AMELIORATING OR PREVENTING VIRAL INFECTIONS AND METHODS FOR MAKING AND USING THEM | Topelia Aust Limited (ACN 652 771 670) (AU) | 2026-01-21 | — | — | EP | claimed |
| US-20260000678-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTING, SUPPRESSING, OR TREATING SYMPTOM ASSOCIATED WITH PSEUDO-ALLERGIC REACTION | TAKASAKI UNIV OF HEALTH AND WELFARE (JP) | 2026-01-01 | — | — | US | claimed |
| WO-2025244856-A1 | METHODS AND COMPOSITIONS RELATING TO ELQ COMPOUNDS | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2025-11-27 | — | — | WO | claimed |
| EP-3625238-B1 | NOVEL SPIRO-LACTAM COMPOUNDS, PROCESS AND USES THEREOF | UNIV DE COIMBRA (PT) | 2025-11-26 | — | — | EP | claimed |
| EP-4448107-B1 | DRUG DELIVERY SYSTEMS BASED ON ENDOPEROXIDES USEFUL IN DIAGNOSIS AND THERAPY, AND METHODS THEREOF | FACULDADE DE FARMACIA DA UNIV DE LISBOA (PT) | 2025-11-05 | — | — | EP | claimed |
| US-4532245-A | Pharmaceutical compositions | HOFFMANN-LA ROCHE INC. (US) | 1985-07-30 | — | — | US | claimed |
| EP-0037501-B1 | PHARMACEUTICAL PREPARATIONS AND MANUFACATURE | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-07-18 | — | — | EP | claimed |
| EP-0022342-B1 | SULFONAMIDE SOLUTIONS | PFIZER INC. (US) | 1983-06-15 | — | — | EP | claimed |
| US-4374826-A | SULFADOXINE, TRIMETHOPRIM, 2-PYRROLIDONE | PFIZER INC. (US) | 1983-02-22 | — | — | US | claimed |
| US-4315931-A | MICROBIOCIDES, INFECTIOUS DISEASES | BASF AKTIENGESELLSCHAFT (DE) | 1982-02-16 | — | — | US | claimed |
| US-4284627-A | TETRAHYDROACRIDONE DERIVATIVES | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-08-18 | — | — | US | claimed |
| EP-0001796-B1 | ANTI-MALARIA DRUG | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-06-10 | — | — | EP | claimed |
| EP-0022342-A2 | Sulfonamide solutions | PFIZER INC. (US) | 1981-01-14 | — | — | EP | claimed |
| EP-0001796-A1 | Anti-malaria drug | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-05-16 | — | — | EP | claimed |
| US-4041160-A | N-METHYL-2-PYRROLIDONE, ANTICOCCIDIAL AGENTS | ABIC LTD. (IL) | 1977-08-09 | — | — | US | claimed |