Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfadoxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.86 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | EDNRA | P25101 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfadoxine SCHEMBL41069 | 0.92 | ESR1 (1.00) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL29390814 | 0.92 | ESR1 (1.00) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL27856131 | 0.91 | ESR1 (0.97) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL28436237 | 0.91 | ESR1 (0.97) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL28359083 | 0.91 | ESR1 (0.97) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL28537335 | 0.91 | ESR1 (0.97) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL615997 | 0.88 | ESR1 (0.90) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL28122268 | 0.87 | ESR1 (0.88) | ESR1MEN1KMT2ACYP2C19LMNA | |
| Sulfadoxine SCHEMBL28198178 | 0.84 | ESR1 (0.82) | ESR1MEN1KMT2ACYP2C19LMNA | |
| SCHEMBL27971500 | 0.81 | ESR1 (0.74) | ESR1MEN1KMT2ACYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115128187-A | Method for determining antibiotic medicines in liquid Chinese herbal medicine preparation for fishing | 福建省水产研究所（福建水产病害防治中心） | 2022-09-30 | — | — | CN | disclosed |