SCHEMBL28538341

SCHEMBL28538341

O=C(ON1C(=O)CCC1=O)C1CCC(CNCc2ccc(CO)c([N+](=O)[O-])c2)CC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.39
MEN1 O00255 2/20 0.39
CXCR4 P61073 1/20 0.39
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
ALDH1A1 P00352 3/20 0.33
MAPK1 P28482 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
MAPT P10636 2/20 0.33
HTT P42858 1/20 0.33
NPY1R P25929 1/20 0.33
NPY5R Q15761 1/20 0.33
SIGMAR1 Q99720 1/20 0.33
CASP6 P55212 1/20 0.33
CYP1A2 P05177 1/20 0.32
CYP2D6 P10635 1/20 0.32
SLC6A4 P31645 1/20 0.32
DRD3 P35462 1/20 0.32
OPRK1 P41145 1/20 0.32
HTR2B P41595 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28543717 0.85 S1PR1 (0.32) ALDH1A1MAPK1TDP1MAPT
SCHEMBL29113870 0.85 KMT2A (0.39) KMT2AMEN1CXCR4NPC1RAB9A
SCHEMBL28544775 0.78 CXCR4 (0.44) KMT2AMEN1CXCR4NPC1RAB9A
SCHEMBL28530175 0.75 NPC1 (0.40) KMT2AMEN1NPC1RAB9AALDH1A1
SCHEMBL28539791 0.73 NPC1 (0.39) KMT2ANPC1RAB9AALDH1A1MAPK1
SCHEMBL28551714 0.73 NPC1 (0.39) KMT2ANPC1RAB9AALDH1A1MAPK1
SCHEMBL28530183 0.73 ALDH1A1 (0.41) KMT2AMEN1ALDH1A1MAPK1TDP1
SCHEMBL28542167 0.73 AKR1C4 (0.37) KMT2AMEN1ALDH1A1TDP1MAPT
SCHEMBL28536734 0.72 ALDH1A1 (0.36) KMT2ACXCR4ALDH1A1MAPK1TDP1
SCHEMBL28969702 0.72 PDK1 (0.40) KMT2AMEN1NPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112574089-A Photoinduced multifunctional cross-linking agent, and preparation method and application thereof 中国科学院上海药物研究所 2021-03-30 CN disclosed