Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 6/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29031101 | 0.88 | SMN1; SMN2 (0.52) | MTNR1BEGFRERBB3MAPTTP53 | |
| SCHEMBL28543171 | 0.87 | PDE4B (0.51) | MTNR1BEGFRERBB3MAPTTP53 | |
| SCHEMBL28532052 | 0.85 | HTT (0.56) | MTNR1BEGFRERBB3MAPTTP53 | |
| SCHEMBL28543158 | 0.84 | SMN1; SMN2 (0.53) | MAPTTP53SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL29031128 | 0.80 | SMN1; SMN2 (0.47) | MAPTTP53SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL28545378 | 0.80 | SMN1; SMN2 (0.48) | MAPTTP53SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL28532069 | 0.79 | ALDH1A1 (0.54) | MAPTTP53SMN1; SMN2KDM4ENPC1 | |
| SCHEMBL28545895 | 0.79 | MAPT (0.46) | MAPTSMN1; SMN2KDM4ERAB9AMEN1 | |
| SCHEMBL20338803 | 0.78 | MAPT (0.47) | EGFRERBB3MAPTTP53SMN1; SMN2 | |
| SCHEMBL2828075 | 0.76 | EGFR (0.57) | MTNR1BEGFRERBB3MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111925357-B | Acylhydrazone compound, pharmaceutical composition and application thereof | 中国科学院昆明植物研究所 | 2023-06-06 | — | — | CN | disclosed |
| CN-111925357-A | Acylhydrazone compound, pharmaceutical composition and application thereof | 中国科学院昆明植物研究所 | 2020-11-13 | — | — | CN | disclosed |