Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | DHODH | Q02127 | 4/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28532069 | 0.87 | ALDH1A1 (0.54) | SMN1; SMN2NPC1RAB9AHPGDKDM4E | |
| SCHEMBL28545895 | 0.86 | MAPT (0.46) | SMN1; SMN2RAB9ATSHRKDM4ELMNA | |
| SCHEMBL28532052 | 0.85 | HTT (0.56) | SMN1; SMN2NPC1RAB9AHPGDKDM4E | |
| SCHEMBL29031128 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RAB9AHPGDKDM4E | |
| SCHEMBL29031101 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9AHPGDKDM4E | |
| SCHEMBL28543158 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9ADHODHHPGD | |
| SCHEMBL28537077 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9ATSHRKDM4E | |
| SCHEMBL28540429 | 0.80 | MTNR1B (0.62) | SMN1; SMN2NPC1RAB9AHPGDKDM4E | |
| SCHEMBL28545384 | 0.79 | CYP1A2 (0.43) | SMN1; SMN2NPC1RAB9ADHODHTSHR | |
| SCHEMBL28543171 | 0.79 | PDE4B (0.51) | SMN1; SMN2NPC1RAB9ADHODHKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111925357-B | Acylhydrazone compound, pharmaceutical composition and application thereof | 中国科学院昆明植物研究所 | 2023-06-06 | — | — | CN | disclosed |
| CN-111925357-A | Acylhydrazone compound, pharmaceutical composition and application thereof | 中国科学院昆明植物研究所 | 2020-11-13 | — | — | CN | disclosed |