SCHEMBL28540543

SCHEMBL28540543

CCC1(CC)CC(c2cccc(Cl)c2)CN1S(=O)(=O)c1ccc([N+](=O)[O-])cc1

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 2/20 0.40
FAAH O00519 1/20 0.40
RECQL P46063 2/20 0.39
ALDH1A1 P00352 2/20 0.38
TERT O14746 1/20 0.38
MAPT P10636 1/20 0.38
ACHE P22303 1/20 0.37
KDM1A O60341 1/20 0.37
RCOR1 Q9UKL0 1/20 0.37
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
CACNA1F O60840 1/20 0.35
CACNA1D Q01668 1/20 0.35
CACNA1S Q13698 1/20 0.35
CACNA1C Q13936 1/20 0.35
HTT P42858 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28534735 0.89 MAPT (0.40) MMP2ALDH1A1MAPTACHEHTT
SCHEMBL28541495 0.88 ALDH1A1 (0.40) FAAHRECQLALDH1A1TERTMAPT
SCHEMBL28541517 0.87 MMP2 (0.47) MMP2RECQLALDH1A1ACHEKMT2A
SCHEMBL28542268 0.82 MAPT (0.47) FAAHRECQLALDH1A1MAPTACHE
SCHEMBL28547908 0.82 ALDH1A1 (0.39) MMP2FAAHRECQLALDH1A1MAPT
SCHEMBL28540365 0.81 MAPT (0.46) MMP2FAAHRECQLALDH1A1MAPT
SCHEMBL28551010 0.80 HSD11B1 (0.50) ALDH1A1
SCHEMBL28911265 0.80 ALDH1A1 (0.53) MMP2ALDH1A1MAPTMEN1KMT2A
SCHEMBL28540550 0.78 ALDH1A1 (0.39) MMP2RECQLALDH1A1MAPTACHE
SCHEMBL28910674 0.75 ALDH1A1 (0.48) ALDH1A1MAPTMEN1KMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112608269-B Method for catalytically synthesizing pyrrolidine by weak interaction of chalcogen 山东大学 2022-05-06 CN disclosed
CN-112608269-A Method for catalytically synthesizing pyrrolidine by weak interaction of chalcogen 山东大学 2021-04-06 CN disclosed