Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.59 |
| ▸ | TYK2 | P29597 | 3/20 | 0.55 |
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | GLS | O94925 | 1/20 | 0.54 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | FLT1 | P17948 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28768950 | 0.92 | ROCK1 (0.62) | ROCK1GLSHTTSMN1; SMN2BRAF | |
| SCHEMBL13485755 | 0.80 | GLS (0.53) | ROCK1GLSPOLBBRAFKDM4E | |
| SCHEMBL25110209 | 0.78 | GLS (0.52) | ROCK1GLSPOLBBRAFALDH1A1 | |
| SCHEMBL10061796 | 0.76 | RIPK1 (0.54) | ROCK1GLSRIPK1HTTPOLB | |
| SCHEMBL856957 | 0.76 | POLB (0.52) | ROCK1GLSHTTPOLBSMN1; SMN2 | |
| SCHEMBL17311598 | 0.75 | ROCK1 (1.00) | ROCK1 | |
| SCHEMBL2863502 | 0.75 | ROCK1 (0.54) | ROCK1SMN1; SMN2ALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL11893514 | 0.74 | POLB (0.50) | ROCK1GLSHTTPOLBSMN1; SMN2 | |
| SCHEMBL23780341 | 0.74 | NAPRT (0.43) | ROCK1GLSKDRPOLBSMN1; SMN2 | |
| SCHEMBL10242690 | 0.73 | MAPK1 (0.51) | ROCK1GLSHTTPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |