Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.46 |
| ▸ | GLS | O94925 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | CYP2C18 | P33260 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.41 |
| ▸ | GRN | P28799 | 1/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856957 | 0.85 | POLB (0.52) | MAPK1CYP2C9POLBHCRTR1HCRTR2 | |
| Hydrochloric Acid SCHEMBL11893514 | 0.83 | POLB (0.50) | MAPK1CYP2C9POLBHCRTR1HCRTR2 | |
| SCHEMBL27637327 | 0.82 | PTGS2 (0.50) | ALDH1A1 | |
| SCHEMBL193205 | 0.81 | POLB (0.48) | MAPK1CYP2C9POLBHCRTR1HCRTR2 | |
| SCHEMBL3168308 | 0.81 | POLB (0.53) | CYP2C9POLBHCRTR1HCRTR2GLS | |
| SCHEMBL25110209 | 0.81 | GLS (0.52) | MAPK1CYP2C9POLBHCRTR1HCRTR2 | |
| SCHEMBL17321503 | 0.81 | ALDH1A1 (0.46) | MAPK1CYP2C9POLBHCRTR1HCRTR2 | |
| SCHEMBL18394893 | 0.81 | TP53 (0.50) | CYP2C9POLBHCRTR1HCRTR2GLS | |
| SCHEMBL13485755 | 0.79 | GLS (0.53) | CYP2C9POLBHCRTR1HCRTR2GLS | |
| SCHEMBL31569567 | 0.77 | ALDH1A1 (0.46) | POLBALDH1A1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9957281-B2 | Benzodiazepine derivatives as RSV inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2018-05-01 | — | — | US | disclosed |
| US-20170022221-A1 | BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS | ENANTA PHARMACEUTICALS, INC. | 2017-01-26 | — | — | US | disclosed |
| EP-2604597-B1 | HETEROCYCLIC COMPOUND AND USE THEREOF INHIBITOR OF PHOSPHODIESTERASE 10A | TAKEDA PHARMACEUTICALS CO (JP) | 2017-01-04 | — | — | EP | disclosed |
| US-20150353505-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2015-12-10 | — | — | US | disclosed |
| US-9150588-B2 | Substituted pyridazin-4(1H)-ones as phosphodiesterase 10A inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-10-06 | — | — | US | disclosed |
| EP-2631238-A1 | Spirocyclic inhibitors of serine proteases for the treatment of hcv infections | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-08-28 | — | — | EP | disclosed |
| EP-2604597-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2013-06-19 | — | — | EP | disclosed |
| US-20130137675-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-05-30 | — | — | US | disclosed |
| US-8148373-B2 | Compounds | ASTRAZENECA AB (SE) | 2012-04-03 | — | — | US | disclosed |
| US-20090298807-A1 | Compounds | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | US | disclosed |
| CN-1046724-C | Pyrazolopyridine compounds, pharmaceutical compositions containing them, processes for their preparation and their use | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-11-24 | — | — | CN | disclosed |
| CN-1139928-A | Novel compounds | FUJISAWA PHARMACEUTICAL CO (JP) | 1997-01-08 | — | — | CN | disclosed |
| CN-1031570-C | Pyrazolopyridine compound and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-04-17 | — | — | CN | disclosed |
| CN-1044656-A | Pyrazolopyridine compound and preparation method thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1990-08-15 | — | — | CN | disclosed |
| CN-1031376-A | Pyrazolopyridine compound and preparation method thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1989-03-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353505-A1 | PHTHALAZINONES AND ISOQUINOLINONES AS ROCK INHIBITORS | MYLK, MYLK2, ROCK1 | MAPK1 163/4885CYP2C9 2835/4885POLB 3821/4885 |
| US-20130137675-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | PDE3A, PDE2A, PDE5A | MAPK1 210/4885CYP2C9 487/4885POLB 2535/4885 |
| US-20170022221-A1 | BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS | GABRA5, GABRA1, GABBR2 | MAPK1 2860/4885CYP2C9 62/4885POLB 4513/4885 |
| US-20090298807-A1 | Compounds | PKD1, SLC10A1, ABCB11 | MAPK1 2982/4885CYP2C9 22/4885POLB 3862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.