Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dicloxacillin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 4/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.89 |
| ▸ | HPGD | P15428 | 3/20 | 0.82 |
| ▸ | LMNA | P02545 | 3/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.82 |
| ▸ | MEN1 | O00255 | 1/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.82 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.81 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dicloxacillin SCHEMBL23955 | 0.99 | ABCB11 (1.00) | ABCB11CYP1A2HPGDLMNATDP1 | |
| Dicloxacillin SCHEMBL11407710 | 0.99 | ABCB11 (1.00) | ABCB11CYP1A2HPGDLMNATDP1 | |
| Dicloxacillin SCHEMBL11407716 | 0.99 | ABCB11 (1.00) | ABCB11CYP1A2HPGDLMNATDP1 | |
| Dicloxacillin SCHEMBL11407708 | 0.99 | ABCB11 (1.00) | ABCB11CYP1A2HPGDLMNATDP1 | |
| Dicloxacillin SCHEMBL8727180 | 0.99 | ABCB11 (1.00) | ABCB11CYP1A2HPGDLMNATDP1 | |
| Dicloxacillin SCHEMBL41517 | 0.98 | ABCB11 (0.98) | ABCB11CYP1A2HPGDLMNATDP1 | |
| Dicloxacillin SCHEMBL5595924 | 0.98 | ABCB11 (0.98) | ABCB11CYP1A2HPGDLMNATDP1 | |
| Dicloxacillin SCHEMBL28536434 | 0.98 | ABCB11 (0.98) | ABCB11CYP1A2HPGDLMNATDP1 | |
| Dicloxacillin SCHEMBL4928524 | 0.98 | ABCB11 (0.98) | ABCB11CYP1A2HPGDLMNATDP1 | |
| Dicloxacillin SCHEMBL5549845 | 0.97 | ABCB11 (0.97) | ABCB11CYP1A2HPGDLMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113559264-A | Methods of treating microbial infections including mastitis | 罗达制药公司 | 2021-10-29 | — | — | CN | claimed |
| CN-113144197-A | Method of treating topical microbial infections | 罗达制药公司 | 2021-07-23 | — | — | CN | claimed |
| CN-113144197-A | Method of treating topical microbial infections | 罗达制药公司 | 2021-07-23 | — | — | CN | disclosed |
| CN-111905104-A | Method of treating topical microbial infections | 罗达制药公司 | 2020-11-10 | — | — | CN | disclosed |