SCHEMBL28540968

SCHEMBL28540968

O=CN1CC(Cc2ccccc2)C1

nearest known ligand 0.48

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CCR3 P51677 2/20 0.46
GBA1 P04062 1/20 0.46
TACR3 P29371 1/20 0.45
PRMT3 O60678 1/20 0.42
CARM1 Q86X55 1/20 0.42
PRMT6 Q96LA8 1/20 0.42
PRMT1 Q99873 1/20 0.42
PRMT8 Q9NR22 1/20 0.42
LMNA P02545 1/20 0.42
GAA P10253 1/20 0.42
GRIN2B Q13224 1/20 0.41
ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21763293 0.85 TACR3 (0.55) CCR3TACR3PRMT3CARM1PRMT6
SCHEMBL133620 0.81 CCR3 (0.61) CCR3PRMT3CARM1PRMT6PRMT1
SCHEMBL14930168 0.75 PRMT6 (0.50) CCR3GBA1PRMT3CARM1PRMT6
SCHEMBL21051907 0.72 GBA1 (0.46) CCR3GBA1PRMT3CARM1PRMT6
SCHEMBL13554188 0.72 PRMT6 (0.51) CCR3GBA1PRMT3CARM1PRMT6
SCHEMBL19889042 0.72 TACR3 (0.52) TACR3LMNAGAAGRIN2B
SCHEMBL10388535 0.71 POLB (0.49) GBA1
SCHEMBL674276 0.71 GBA1 (0.71) CCR3GBA1PRMT3CARM1PRMT6
SCHEMBL2027845 0.71 GBA1 (0.71) CCR3GBA1PRMT3CARM1PRMT6
SCHEMBL17609543 0.71 GRIN2B (0.47) CCR3GBA1PRMT3CARM1PRMT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112566636-A Compound and use thereof 优曼尼蒂治疗公司 2021-03-26 CN disclosed