Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14297335 | 0.89 | POLB (0.78) | POLBMAPTKMT2AMEN1CYP3A4 | |
| SCHEMBL10572999 | 0.88 | POLB (0.77) | POLBMAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2854488 | 0.86 | ALDH1A1 (0.64) | POLBKMT2AMEN1SMN1; SMN2L3MBTL1 | |
| SCHEMBL10573098 | 0.84 | KMT2A (0.57) | POLBMAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2856152 | 0.80 | POLB (0.57) | POLBMAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6015559 | 0.80 | TAS1R3 (0.63) | MAPTKMT2AMEN1CYP3A4SMN1; SMN2 | |
| SCHEMBL10578507 | 0.79 | L3MBTL1 (0.51) | POLBMAPTKMT2AMEN1CYP3A4 | |
| SCHEMBL31380220 | 0.79 | SRC (0.69) | MAPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5032696 | 0.79 | POLB (0.58) | POLBKMT2AMEN1SMN1; SMN2L3MBTL1 | |
| SCHEMBL14363065 | 0.79 | KMT2A (0.85) | POLBMAPTKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |