Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28544660 | 0.85 | LMNA (0.46) | LMNAS1PR3PTGDR2MAPK1APEX1 | |
| SCHEMBL28543014 | 0.83 | LMNA (0.44) | LMNAS1PR3PTGDR2MAPK1APEX1 | |
| SCHEMBL28535194 | 0.83 | SLC6A9 (0.44) | LMNAS1PR3PTGDR2SCN9ASLC6A9 | |
| SCHEMBL28534841 | 0.83 | SCN9A (0.48) | LMNAS1PR3PTGDR2SCN9ASLC6A9 | |
| SCHEMBL2574654 | 0.80 | S1PR3 (0.57) | LMNAS1PR3PTGDR2MAPK1SLC6A9 | |
| SCHEMBL6630953 | 0.78 | S1PR3 (0.65) | LMNAS1PR3PTGDR2MAPK1SLC6A9 | |
| SCHEMBL28549312 | 0.77 | BRD4 (0.47) | BRD4PTGDR2SCN9ASMN1; SMN2 | |
| SCHEMBL2824930 | 0.77 | SLC6A9 (0.59) | LMNAS1PR3BRD4SLC6A9KCNH2 | |
| SCHEMBL4130038 | 0.77 | S1PR3 (0.71) | LMNAS1PR3PTGDR2MAPK1SLC6A9 | |
| SCHEMBL2825627 | 0.77 | LMNA (0.51) | LMNAS1PR3PTGDR2MAPK1SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105712952-B | 2-substituted oxy-5-methylsulfonyl phenyl piperazine amide analogue and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2021-03-26 | — | — | CN | disclosed |