Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 10/20 | 0.58 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2861063 | 0.93 | CCR1 (0.57) | CCR1TRPC3P2RX7KDM4EALDH1A1 | |
| SCHEMBL2855580 | 0.85 | CCR1 (0.62) | CCR1TRPC3KDM4EALDH1A1MAPT | |
| SCHEMBL2855565 | 0.85 | CCR1 (0.66) | CCR1TRPC3KDM4EALDH1A1MAPT | |
| SCHEMBL2859933 | 0.84 | CCR1 (0.80) | CCR1MAPTHSP90AA1NPSR1 | |
| SCHEMBL2861423 | 0.83 | P2RX7 (0.46) | CCR1TRPC3P2RX7MAPTHSP90AA1 | |
| SCHEMBL2851005 | 0.82 | P2RX7 (0.66) | CCR1TRPC3P2RX7KDM4EALDH1A1 | |
| SCHEMBL2856181 | 0.81 | CCR1 (0.56) | CCR1TRPC3P2RX7KDM4EALDH1A1 | |
| SCHEMBL2852015 | 0.80 | CCR1 (0.63) | CCR1TRPC3KDM4EALDH1A1MAPT | |
| SCHEMBL2854425 | 0.80 | CCR1 (0.60) | CCR1TRPC3KDM4EALDH1A1MAPT | |
| SCHEMBL10365015 | 0.80 | TRPC3 (0.70) | CCR1TRPC3KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |