Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | PRKCB | P05771 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28558723 | 0.86 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL28554390 | 0.84 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DELANE | |
| SCHEMBL14737720 | 0.78 | PGR (0.39) | HTTCNR1CNR2L3MBTL1MPO | |
| SCHEMBL14738488 | 0.77 | GRM4 (0.35) | PDE4APDE4BPDE4CPDE4DCNR1 | |
| SCHEMBL1278237 | 0.70 | NOS3 (0.38) | MAPTL3MBTL1TDP1 | |
| SCHEMBL12329416 | 0.70 | KDM4D (0.45) | PDE4APDE4BPDE4CPDE4DELANE | |
| SCHEMBL31319295 | 0.70 | NOS3 (0.38) | MAPTL3MBTL1TDP1 | |
| SCHEMBL1671404 | 0.69 | CYP2D6 (0.32) | PDE4APDE4BPDE4CPDE4DL3MBTL1 | |
| SCHEMBL15913345 | 0.69 | KDM4E (0.33) | CNR2L3MBTL1TDP1 | |
| SCHEMBL29382435 | 0.69 | CYP2C9 (0.40) | L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109535158-B | Bisaryl maleimide compound and pharmaceutically acceptable salt thereof, and preparation method and application thereof | 浙江工业大学 | 2021-04-23 | — | — | CN | disclosed |