Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28558723 | 0.90 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DL3MBTL1 | |
| SCHEMBL28545129 | 0.84 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DL3MBTL1 | |
| SCHEMBL13562830 | 0.72 | L3MBTL1 (0.67) | L3MBTL1MAPTHTTADORA2ARET | |
| SCHEMBL30509506 | 0.71 | L3MBTL1 (0.45) | PDE4APDE4BPDE4CPDE4DL3MBTL1 | |
| SCHEMBL12329417 | 0.71 | L3MBTL1 (0.45) | PDE4APDE4BPDE4CPDE4DL3MBTL1 | |
| SCHEMBL31319295 | 0.69 | NOS3 (0.38) | L3MBTL1MAPT | |
| SCHEMBL1278237 | 0.69 | NOS3 (0.38) | L3MBTL1MAPT | |
| SCHEMBL12299464 | 0.69 | L3MBTL1 (0.43) | PDE4APDE4BPDE4CPDE4DL3MBTL1 | |
| SCHEMBL20927208 | 0.69 | L3MBTL1 (0.43) | PDE4APDE4BPDE4CPDE4DL3MBTL1 | |
| SCHEMBL14737310 | 0.69 | KMO (0.38) | ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109535158-B | Bisaryl maleimide compound and pharmaceutically acceptable salt thereof, and preparation method and application thereof | 浙江工业大学 | 2021-04-23 | — | — | CN | disclosed |