SCHEMBL28545272

SCHEMBL28545272

CC(=O)ON1CCC(c2nccnc2OCc2ccc(Cl)cc2F)CC1

nearest known ligand 0.43

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.41
GLP1R P43220 11/20 0.41
KDM5A P29375 1/20 0.39
KDM5B Q9UGL1 1/20 0.39
HTR6 P50406 1/20 0.39
P2RX7 Q99572 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL28911105 0.99 KCNH2 (0.41) KCNH2GLP1RKDM5AKDM5BHTR6
SCHEMBL28543738 0.87 P2RX7 (0.43) GLP1RHTR6P2RX7
Acetic Acid SCHEMBL28911106 0.86 GLP1R (0.42) KCNH2GLP1RKDM5AKDM5B
SCHEMBL23235750 0.85 KDM5A (0.43) KCNH2GLP1RKDM5AKDM5BP2RX7
SCHEMBL23235743 0.83 GLP1R (0.45) KCNH2GLP1RKDM5AKDM5B
SCHEMBL25089758 0.83 KCNH2 (0.48) KCNH2GLP1RHTR6
Ammonia Solution, Strong SCHEMBL30269661 0.83 GLP1R (0.44) KCNH2GLP1RKDM5AKDM5B
SCHEMBL23928974 0.82 FNTA (0.46)
SCHEMBL30269649 0.81 KCNH2 (0.43) KCNH2GLP1R
SCHEMBL28540333 0.79 MEN1 (0.42) KDM5AKDM5B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112566637-B GLP-1 receptor agonists and uses thereof 辉瑞公司 2023-11-14 CN disclosed
CN-112566637-A GLP-1 receptor agonists and uses thereof 辉瑞公司 2021-03-26 CN disclosed