Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 6/20 | 0.41 |
| ▸ | HTR5A | P47898 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.39 |
| ▸ | HTR3B | O95264 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 2/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2852004 | 0.83 | HRH1 (0.49) | HTR2AHTR2CHRH1ADRA1BKCNH2 | |
| SCHEMBL2848519 | 0.82 | HRH1 (0.43) | HRH1ADRA1BKCNH2HRH3 | |
| SCHEMBL2850767 | 0.82 | HRH1 (0.51) | HTR2CSLC6A4HRH1ADRA1BKCNH2 | |
| SCHEMBL2856703 | 0.81 | HRH1 (0.52) | HTR2AHTR2CHRH1ADRA1BKCNH2 | |
| SCHEMBL3919075 | 0.80 | HRH1 (0.42) | HRH1ADRA1BKCNH2HRH3HTR1A | |
| SCHEMBL2852759 | 0.80 | HTR6 (0.50) | HTR2AHTR2CSLC6A4HRH1KCNH2 | |
| SCHEMBL4014210 | 0.78 | HTR2A (0.58) | HTR2AHTR2CSLC6A4HTR6HTR5A | |
| SCHEMBL3715449 | 0.76 | PIM2 (0.44) | HRH1 | |
| SCHEMBL2854918 | 0.76 | KDM4E (0.45) | CYP1A2NCF1HSD17B10CYP2C19KDM4E | |
| SCHEMBL5223620 | 0.73 | HTR2A (0.58) | HTR2AHTR2CSLC6A4HTR6HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027108-B1 | HISTAMINE RECEPTOR ANTAGONISTS COMPRISING AN AZEPIN CORE | GLAXO GROUP LTD (GB) | 2010-01-13 | — | — | EP | disclosed |
| US-20090181950-A1 | Histamine Receptor Antagonists Comprising an Azepin Core | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | US | disclosed |
| EP-2027108-A1 | HISTAMINE RECEPTOR ANTAGONISTS COMPRISING AN AZEPIN CORE | Glaxo Group Limited (GB) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007135081-A1 | HISTAMINE RECEPTOR ANTAGONISTS COMPRISING AN AZEPIN CORE | GLAXO GROUP LIMITED (GB) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181950-A1 | Histamine Receptor Antagonists Comprising an Azepin Core | HRH2, HRH1, HRH4 | HTR2A 54/4885HTR2C 68/4885SLC6A4 1166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.