Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.44 |
| ▸ | PIM1 | P11309 | 4/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.39 |
| ▸ | TOP2A | P11388 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3714317 | 0.81 | HRH1 (0.42) | HRH1 | |
| SCHEMBL3719292 | 0.81 | PIM1 (0.51) | PIM2PIM1JAK2JAK1TYK2 | |
| SCHEMBL2854561 | 0.76 | HTR2A (0.47) | HRH1 | |
| SCHEMBL3717576 | 0.74 | LMNA (0.47) | MCHR1HRH1 | |
| SCHEMBL3717118 | 0.74 | PIM1 (0.57) | PIM2PIM1JAK2JAK1TYK2 | |
| SCHEMBL2854918 | 0.74 | KDM4E (0.45) | PIM1PDE10A | |
| SCHEMBL3713221 | 0.74 | HRH3 (0.60) | HRH1 | |
| SCHEMBL7420604 | 0.73 | KDM4E (0.51) | PDE10A | |
| SCHEMBL2851009 | 0.72 | PDE10A (0.41) | PDE10A | |
| SCHEMBL22365344 | 0.71 | HRH1 (0.58) | HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010094643-A1 | QUINOLINE DERIVATIVES AND THEIR USES FOR RHINITIS AND URTICARIA | GLAXO GROUP LIMITED (GB) | 2010-08-26 | — | — | WO | disclosed |