Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 5/20 | 0.49 |
| ▸ | HTR5A | P47898 | 2/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3560188 | 0.81 | HTR2A (0.63) | HTR2AHTR2CSLC6A4HTR1AHTR6 | |
| SCHEMBL5372201 | 0.80 | HTR2A (0.58) | HTR2AHTR2CSLC6A4HTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL4008999 | 0.79 | HTR2A (0.61) | HTR2AHTR2CSLC6A4HTR1AHTR6 | |
| SCHEMBL2854561 | 0.78 | HTR2A (0.47) | HTR2AHTR2CSLC6A4HTR1ADRD2 | |
| SCHEMBL4968929 | 0.78 | HTR2A (0.63) | HTR2AHTR2CSLC6A4HTR1ADRD2 | |
| SCHEMBL5223620 | 0.77 | HTR2A (0.58) | HTR2AHTR2CSLC6A4HTR1ADRD2 | |
| SCHEMBL5379037 | 0.77 | HTR2A (0.58) | HTR2AHTR2CSLC6A4HTR1ADRD2 | |
| SCHEMBL5373371 | 0.77 | HTR2A (0.58) | HTR2AHTR2CSLC6A4HTR1ADRD2 | |
| SCHEMBL21414484 | 0.76 | ADRB1 (0.45) | HTR2AHTR2CHTR1ADRD2DRD4 | |
| SCHEMBL5217823 | 0.74 | ALDH1A1 (0.58) | HTR2AHTR2CSLC6A4HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080675-A1 | QUINOLINE DERIVATIVES WITH AFFINITY FOR THE 5-HT2B RECEPTOR | GLAXO GROUP LIMITED (GB) | 2009-07-02 | — | — | WO | disclosed |