Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.67 |
| ▸ | SPR | P35270 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | CCR1 | P32246 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850603 | 0.88 | HPGD (0.73) | NPSR1SPRMAPTCCR1KDM4E | |
| SCHEMBL2857896 | 0.85 | HPGD (0.77) | SPRMAPTKDM4EHPGDTP53 | |
| SCHEMBL2857860 | 0.82 | CCR1 (0.75) | NPSR1SPRMAPTCCR1HPGD | |
| SCHEMBL2854061 | 0.82 | HPGD (0.84) | NPSR1SPRMAPTCCR1KDM4E | |
| SCHEMBL2854347 | 0.82 | HPGD (0.84) | NPSR1SPRMAPTCCR1KDM4E | |
| SCHEMBL2851942 | 0.81 | NPC1 (0.64) | SPRMAPTKDM4EHPGDTP53 | |
| SCHEMBL2855676 | 0.81 | CCR1 (0.63) | NPSR1SPRMAPTCCR1HPGD | |
| SCHEMBL13485753 | 0.80 | NPC1 (0.57) | NPSR1MAPTCCR1KDM4EHPGD | |
| SCHEMBL18711816 | 0.80 | SPR (1.00) | SPR | |
| SCHEMBL2857468 | 0.80 | MAPT (0.47) | NPSR1SPRMAPTCCR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |