Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.77 |
| ▸ | NPC1 | O15118 | 9/20 | 0.62 |
| ▸ | RAB9A | P51151 | 9/20 | 0.62 |
| ▸ | SPR | P35270 | 1/20 | 0.61 |
| ▸ | CNR1 | P21554 | 1/20 | 0.60 |
| ▸ | CNR2 | P34972 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | EED | O75530 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2851942 | 0.90 | NPC1 (0.64) | HPGDNPC1RAB9ASPRNFKB1 | |
| SCHEMBL2856089 | 0.87 | HPGD (1.00) | HPGDNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL2854579 | 0.85 | NPSR1 (0.67) | HPGDNPC1RAB9ASPRMAPT | |
| SCHEMBL2605692 | 0.84 | HPGD (0.76) | HPGDNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL2852043 | 0.81 | KDM4E (0.70) | HPGDNPC1RAB9ACNR1CNR2 | |
| SCHEMBL28704189 | 0.81 | HPGD (0.71) | HPGDNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL10367090 | 0.79 | HPGD (0.72) | HPGDNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL2854347 | 0.79 | HPGD (0.84) | HPGDNPC1RAB9ASPRMAPT | |
| SCHEMBL2854061 | 0.79 | HPGD (0.84) | HPGDNPC1RAB9ASPRNFKB1 | |
| SCHEMBL2852350 | 0.79 | NPC1 (0.53) | HPGDNPC1RAB9ACNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |