Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2855767 | 0.90 | P2RX1 (0.47) | KEAP1NFE2L2MAPTCA1CA2 | |
| SCHEMBL2855798 | 0.90 | MAPT (0.45) | KEAP1NFE2L2MAPTCA1CA2 | |
| SCHEMBL2852372 | 0.90 | MAPT (0.48) | MAPTCA1CA2CA4CA7 | |
| SCHEMBL2859466 | 0.89 | MAPT (0.46) | KEAP1NFE2L2MAPTCA1CA2 | |
| SCHEMBL2863249 | 0.88 | LMNA (0.48) | MAPTKMT2AMEN1NPSR1LMNA | |
| SCHEMBL2848317 | 0.88 | MAPT (0.46) | KEAP1NFE2L2MAPTBRAFKMT2A | |
| SCHEMBL2852249 | 0.87 | MAPT (0.43) | KEAP1NFE2L2MAPTCA1CA2 | |
| SCHEMBL2850258 | 0.87 | MAPT (0.51) | MAPTBRAFKMT2AMEN1NPSR1 | |
| SCHEMBL2860427 | 0.86 | MAPT (0.48) | KEAP1NFE2L2MAPTKMT2AMEN1 | |
| SCHEMBL2856626 | 0.85 | EPHX2 (0.53) | MAPTKMT2AMEN1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |