Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 10/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28539777 | 0.83 | MAPT (0.40) | ALDH1A1LMNAMAPTKDM4EKMT2A | |
| SCHEMBL28546189 | 0.79 | MAPT (0.47) | ALDH1A1LMNAL3MBTL1CYP2D6MAPT | |
| SCHEMBL28537173 | 0.78 | MAPT (0.55) | ALDH1A1LMNAL3MBTL1CYP2D6MAPT | |
| SCHEMBL22321541 | 0.77 | MAPT (0.47) | ALDH1A1LMNAL3MBTL1CYP2D6MAPT | |
| SCHEMBL28537399 | 0.75 | MAPT (0.33) | L3MBTL1MAPTKMT2ASMN1; SMN2HTT | |
| SCHEMBL21596369 | 0.72 | GAA (0.50) | ALDH1A1LMNAMAPTKDM4EKMT2A | |
| SCHEMBL28539775 | 0.72 | ALDH1A1 (0.39) | ALDH1A1LMNACYP2D6MAPTKDM4E | |
| SCHEMBL1421217 | 0.72 | ALDH1A1 (0.42) | ALDH1A1L3MBTL1MAPTKDM4EKMT2A | |
| SCHEMBL21596314 | 0.71 | GAA (0.58) | LMNAMAPTKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL28526641 | 0.70 | KDM4E (0.36) | ALDH1A1MAPTKDM4EKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-113087671-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2022-10-21 | — | — | CN | disclosed |
| CN-113087671-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-07-09 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |